-| Washington University School of Medicine | Department of Molecular Microbiology | Division of Biology and Biomedical Sciences | Molecular Microbiology Program |-

Hultgren Lab
Publications

Publications 2000-2001

2001

Svensson A, Larsson A, Emtenas H, Hedenstrom M, Fex T, Hultgren SJ, Pinkner JS, Almqvist F, Kihlberg J.
Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli.
Chembiochem. 2001 Dec 3;2(12):915-8.
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Smith CL, Hultgren SJ.
Bacteria thread the needle.
Nature. 2001 Nov 1;414(6859):29-31.
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Mulvey MA, Schilling JD, Hultgren SJ.
Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection.
Infect Immun. 2001 Jul;69(7):4572-9.
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Dodson KW, Pinkner JS, Rose T, Magnusson G, Hultgren SJ, Waksman G.
Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell. 2001 Jun 15;105(6):733-43.
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Hultgren SJ.
Uropathogenic escherichia coli: interactions with bladder epithelium.
Urology. 2001 Jun;57(6 Suppl 1):105-6.
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Schilling JD, Mulvey MA, Hultgren SJ.
Dynamic interactions between host and pathogen during acute urinary tract infections.
Urology. 2001 Jun;57(6 Suppl 1):56-61.
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Hung DL, Raivio TL, Jones CH, Silhavy TJ, Hultgren SJ.
Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili.
EMBO J. 2001 Apr 2;20(7):1508-18.
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Schilling JD, Mulvey MA, Hultgren SJ.
Structure and function of Escherichia coli type 1 pili: new insight into the pathogenesis of urinary tract infections.
J Infect Dis. 2001 Mar 1;183 Suppl 1:S36-40.
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Schilling JD, Mulvey MA, Vincent CD, Lorenz RG, Hultgren SJ.
Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism.
J Immunol. 2001 Jan 15;166(2):1148-55.
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2000

Sauer FG, Barnhart M, Choudhury D, Knight SD, Waksman G, Hultgren SJ.
Chaperone-assisted pilus assembly and bacterial attachment.
Curr Opin Struct Biol. 2000 Oct;10(5):548-56.
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Mahmood A, Engle MJ, Hultgren SJ, Goetz GS, Dodson K, Alpers DH.
Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli.
Biochim Biophys Acta. 2000 Sep 1;1523(1):49-55.
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Mulvey MA, Hultgren SJ.
Cell biology. Bacterial spelunkers.
Science. 2000 Aug 4;289(5480):732-3.
Online

Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ.
Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses.
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8829-35.
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Saulino ET, Bullitt E, Hultgren SJ.
Snapshots of usher-mediated protein secretion and ordered pilus assembly.
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9240-5.
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Thanassi DG, Hultgren SJ.
Multiple pathways allow protein secretion across the bacterial outer membrane.
Curr Opin Cell Biol. 2000 Aug;12(4):420-30.

Stathopoulos C, Hendrixson DR, Thanassi DG, Hultgren SJ, St Geme JW 3rd, Curtiss R 3rd.
Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.
Microbes Infect. 2000 Jul;2(9):1061-72.
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Emtenas H, Soto G, Hultgren SJ, Marshall GR, Almqvist F.
Stereoselective synthesis of optically active beta-lactams, potential inhibitors of pilus assembly in pathogenic bacteria.
Org Lett. 2000 Jul 13;2(14):2065-7.
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Barnhart MM, Pinkner JS, Soto GE, Sauer FG, Langermann S, Waksman G, Frieden C, Hultgren SJ.
PapD-like chaperones provide the missing information for folding of pilin proteins.
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7709-14.
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Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ.
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells.
EMBO J. 2000 Jun 15;19(12):2803-12.
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Krasan GP, Sauer FG, Cutter D, Farley MM, Gilsdorf JR, Hultgren SJ, St Geme JW 3rd
Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili.
Mol Microbiol. 2000 Mar;35(6):1335-47.
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Lopez-Boado YS, Wilson CL, Hooper LV, Gordon JI, Hultgren SJ, Parks WC.
Bacterial exposure induces and activates matrilysin in mucosal epithelial cells.
J Cell Biol. 2000 Mar 20;148(6):1305-15.
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Sauer FG, Knight SD, Waksman and GJ, Hultgren SJ.
PapD-like chaperones and pilus biogenesis.
Semin Cell Dev Biol. 2000 Feb;11(1):27-34.
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Sauer FG, Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ.
Bacterial pili: molecular mechanisms of pathogenesis.
Curr Opin Microbiol. 2000 Feb;3(1):65-72.

Langermann S, Mollby R, Burlein JE, Palaszynski SR, Auguste CG, DeFusco A, Strouse R, Schenerman MA, Hultgren SJ, Pinkner JS, Winberg J, Guldevall L, Soderhall M, Ishikawa K, Normark S, Koenig S.
Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli.
J Infect Dis. 2000 Feb;181(2):774-8.
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Thanassi DG, Hultgren SJ.
Assembly of complex organelles: pilus biogenesis in gram-negative bacteria as a model system.
Methods. 2000 Jan;20(1):111-26.
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